Abbott W C, Grakauskas A M, Bistrian B R, Rose R, Blackburn G L
Arch Surg. 1984 Dec;119(12):1367-71. doi: 10.1001/archsurg.1984.01390240005001.
Intravenous hyperalimentation with dextrose can be associated with adverse respiratory and hepatic effects. The purpose of this study was to determine the respiratory and metabolic consequences of fat calories in excess of resting energy expenditure provided both continuously and discontinuously. No significant changes in respiratory mechanics, oxygen consumption, carbon dioxide production, resting energy expenditure, serum substrates, liver function, or nitrogen balance were noted by the addition of 500 kcal of lipid emulsion to dextrose calories sufficient to meet energy requirements. The respiratory quotient declined significantly with the 12- and 24-hour lipid infusions, but persisted for the entire 24 hours only in the latter instance. The sustained and increased (46% v 36%) oxidation of lipid with a 24-hour infusion suggests that a continuous infusion of lipid is preferable to a discontinuous infusion.
静脉输注葡萄糖进行肠外营养可能会产生不良的呼吸和肝脏影响。本研究的目的是确定连续和间断提供超过静息能量消耗的脂肪热量所带来的呼吸和代谢后果。在足以满足能量需求的葡萄糖热量中添加500千卡脂质乳剂后，未观察到呼吸力学、氧消耗、二氧化碳产生、静息能量消耗、血清底物、肝功能或氮平衡有显著变化。在输注脂质12小时和24小时时，呼吸商显著下降，但仅在后者的情况下在整个24小时内持续下降。24小时输注脂质时脂质氧化持续增加（46%对36%），这表明连续输注脂质优于间断输注。
