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人载脂蛋白CIII基因以及载脂蛋白AI和载脂蛋白CIII基因之间基因间区域的分离与序列分析。

Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes.

作者信息

Protter A A, Levy-Wilson B, Miller J, Bencen G, White T, Seilhamer J J

出版信息

DNA. 1984 Dec;3(6):449-56. doi: 10.1089/dna.1.1984.3.449.

DOI:10.1089/dna.1.1984.3.449
PMID:6439535
Abstract

We have isolated and characterized the gene for human apolipoprotein CIII, a major component of the triglyceride-rich lipoproteins. Determination of the complete DNA sequence of this gene revealed that the coding sequence is interrupted by three introns, which occur in the 5' noncoding region, in the region encoding the signal sequence and in the region coding for the mature plasma protein, respectively. We present an analysis of the structure of the apo CIII gene and compare it to the gene for apolipoprotein AI. In addition, we present the DNA sequence of the intergenic region lying between the apo AI and the apo CIII genes.

摘要

我们已经分离并鉴定了人类载脂蛋白CIII的基因，它是富含甘油三酯脂蛋白的主要成分。该基因完整DNA序列的测定表明，编码序列被三个内含子打断，它们分别出现在5'非编码区、编码信号序列的区域以及编码成熟血浆蛋白的区域。我们对载脂蛋白CIII基因的结构进行了分析，并将其与载脂蛋白AI的基因进行了比较。此外，我们还给出了位于载脂蛋白AI和载脂蛋白CIII基因之间的基因间区域的DNA序列。

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1
Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes.人载脂蛋白CIII基因以及载脂蛋白AI和载脂蛋白CIII基因之间基因间区域的分离与序列分析。
DNA. 1984 Dec;3(6):449-56. doi: 10.1089/dna.1.1984.3.449.
2
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引用本文的文献

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A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.APOC3基因中的一种罕见变异与欧洲人的血浆甘油三酯和极低密度脂蛋白水平相关。
Nat Commun. 2014 Sep 16;5:4871. doi: 10.1038/ncomms5871.
2
An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.一种对高甘油三酯血症具有保护作用的载脂蛋白CIII单倍型由启动子和3'非翻译区多态性所决定。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4562-6. doi: 10.1073/pnas.90.10.4562.
3
Extracoronary atherosclerosis and genetic variants of apolipoprotein AI-CIII cluster in myocardial infarction survivors from southern Italy.
意大利南部心肌梗死幸存者中的冠状动脉外动脉粥样硬化与载脂蛋白AI-CIII基因变异簇
Clin Investig. 1994 Jun;72(6):435-41. doi: 10.1007/BF00180517.
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Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.载脂蛋白多基因家族：人载脂蛋白AI、CIII和AIV基因的串联排列
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Similar molecular deletions on chromosome 15q11.2 are encountered in both the Prader-Willi and Angelman syndromes.普拉德-威利综合征和安吉尔曼综合征中均会出现15号染色体长臂1区1带2亚带（15q11.2）上类似的分子缺失。
Hum Genet. 1988 Dec;80(4):322-8. doi: 10.1007/BF00273644.
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J Mol Evol. 1988;27(1):45-55. doi: 10.1007/BF02099729.
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