DiPiro J T, Bowden T A, Hooks V H
JAMA. 1984 Dec 21;252(23):3277-9.
Parenteral prophylactic cephalosporins used in surgery were compared in 17 published studies. Examination of these studies reveals little justification for preference of one cephalosporin over another. For gastrointestinal, obstetrical-gynecologic, or cardiac operations, newer cephalosporins did not result in substantial decreases in adverse postoperative clinical events (eg, wound infections, intra-abdominal and pelvic infections, and endocarditis) when compared with older cephalosporins. There is no evidence that second- or third-generation cephalosporins result in postoperative infection rates lower than with first-generation cephalosporins.
17项已发表的研究对手术中使用的胃肠外预防性头孢菌素进行了比较。对这些研究的审查表明，几乎没有理由偏爱一种头孢菌素而不喜欢另一种。对于胃肠道、妇产科或心脏手术，与较老的头孢菌素相比，更新的头孢菌素在术后不良临床事件（如伤口感染、腹腔和盆腔感染以及心内膜炎）方面并未导致大幅下降。没有证据表明第二代或第三代头孢菌素导致的术后感染率低于第一代头孢菌素。
