测定双氢麦角汀（DEC）对人促甲状腺激素释放激素（TRH）刺激的催乳素的抑制作用：生物利用度的间接评估。
Measuring the inhibition of TRH-stimulated prolactin by dihydroergocristine (DEC) in man: an indirect assessment of bioavailability.
作者信息
Venitz J, Lücker P W, Albrecht H, Mailland F
出版信息
Methods Find Exp Clin Pharmacol. 1984 Oct;6(10):645-7.
PMID:6439963
Abstract
An indirect method to assess bioavailability of dihydroergocristine-methansulfonate (DEC) is described. The method uses the inhibitory effect of DEC on TRH stimulated prolactin production. By means of this method it was possible to investigate the relative bioavailability of DEC tablets versus Diertina liquid. The results show that the relative bioavailability is complete.
摘要
描述了一种评估甲磺酸二氢麦角隐亭（DEC）生物利用度的间接方法。该方法利用DEC对促甲状腺激素释放激素（TRH）刺激的催乳素分泌的抑制作用。通过这种方法，可以研究DEC片剂相对于Diertina液剂的相对生物利用度。结果表明相对生物利用度是完全的。
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