曲匹地尔衍生物对花生四烯酸和前列腺素内过氧化物类似物诱导的血小板聚集及血栓素A2形成的影响。
Influence of trapidil derivatives on arachidonic acid- and prostaglandin endoperoxide analogue- induced platelet aggregation and thromboxane A2 formation.
作者信息
Heinroth I, Block H U, Mest H J
出版信息
Biomed Biochim Acta. 1984;43(8-9):S389-92.
PMID:6440555
Abstract
Five selected trapidil derivatives (12456, 12460, 12463, 12464, 12465) inhibited the arachidonic acid(AA)- and prostaglandin endoperoxide analogue(U-46619)- induced platelet aggregation as well as the AA- induced thromboxane A2(TXA2) formation. These effects of the derivatives were generally more markedly expressed than those of trapidil.
摘要
五种选定的曲匹地尔衍生物（12456、12460、12463、12464、12465）抑制花生四烯酸（AA）和前列腺素内过氧化物类似物（U-46619）诱导的血小板聚集以及AA诱导的血栓素A2（TXA2）形成。这些衍生物的这些作用通常比曲匹地尔的作用表现得更明显。
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