[The effect of a novel TRH analog (DN-1417) on postictal seizure inhibition in amygdaloid kindled cats].

Anticonvulsant and prophylactic effects of DN-1417, a novel TRH analog, were reported previously in kindled cat preparations which had been established as an experimental model of epilepsy. This study was conducted to examine an effect of DN-1417 on postictal events including postictal seizure inhibition (PSI). A recycling paradigm consisted of 8 amygdaloid stimuli at 1 hour intervals was applied to evaluate the PSI. Six of bilateral amygdaloid kindled cats were used. In control session, the left amygdala had been stimulated at final electroconvulsive threshold at 1 hour intervals in all cats. In drug session, the cats were pretreated with DN-1417 (4 mg/kg, i.v.) and exposed to recycling paradigm 20 minutes after the administration. The interval of each session was at least 2 weeks EEG recordings and behavioral observations were carried out at the same time. Effects of TRH tartrate (4 mg/kg, i.v.) on PSI was also investigated in 2 cats at the same paradigm. PSI was significantly prolonged and postictal EEG silence was significantly shortened by DN-1417. The pretreatment of TRH tartrate showed an prolongation of PSI in 2 cats respectively. These results suggest that administrated TRH analog or TRH may inhibit an occurrence of subsequent seizures and prevent the epileptic status.