[Demonstration, during the regeneration of urodeles, of a dedifferentiating influence of cicatricial epithelium (study in Salamandra salamandra larvae)].

Grafts of wound epithelium have been performed on non-amputated limbs and blastema cells have been cultured alone or in the presence of normal epidermis and wound epithelium extracts. These experiments have shown a dedifferentiating and cytotoxic effect of wound epithelium. This effect appears governed by enzymes acting on the extracellular matrix and cell surfaces.