Jakse G
Eur Urol. 1984;10(5):289-93. doi: 10.1159/000463813.
46 patients with carcinoma in situ of the urinary bladder were treated with intracavitary chemotherapy. The mean follow-up was 33 months. Tumor remission, defined by negative cytology and no evidence of TIS or severe dysplasia on biopsy, was achieved in 78%. There were 6 deaths, but only 1 was due to bladder cancer. 22 patients were followed after the termination of the planned treatment protocol. Recurrence of carcinoma in situ or development of a superficial bladder cancer was observed in 10 (45%). Bladder biopsies performed at the end of treatment were of no predictive value with regard to tumor recurrence. Tumor remission was achieved in all patients who received repeated intracavitary chemotherapy.
46例膀胱原位癌患者接受了腔内化疗。平均随访时间为33个月。78%的患者实现了肿瘤缓解，其定义为细胞学检查阴性且活检无原位癌或重度发育异常证据。有6例死亡，但仅1例死于膀胱癌。22例患者在预定治疗方案结束后接受随访。10例（45%）观察到原位癌复发或浅表性膀胱癌的发生。治疗结束时进行的膀胱活检对肿瘤复发无预测价值。所有接受重复腔内化疗的患者均实现了肿瘤缓解。
