Nguyen T D, Demange L, Froissart D, Panis X, Loirette M
Radiother Oncol. 1984 Dec;2(4):313-6. doi: 10.1016/s0167-8140(84)80073-0.
Seven patients with large cervical node metastases were treated at the Institut Jean-Godinot using a particular scheme of accelerated irradiation. Conventional Cobalt-60 radiotherapy was prophylactically delivered to extended volumes of the neck (50 Gy in 25 fractions over 5 weeks). Within the fields of cobalt irradiation, an electron beam field was added to increase the daily dose from 2 to 3 Gy (Fletcher's field in the field technique). The increment of dose was limited to nodal area. Since no interval separated the two irradiations, involved areas were considered to receive 70 Gy in 25 fractions over 5 weeks and non-clinically involved areas to receive 50 Gy in 25 fractions over 5 weeks. In all the cases, the malignant mass diameter exceeded 5 cm. Acute tolerance was good and no major late injury was observed during the 18 months minimum follow-up period. At the end of the treatment, a complete disappearance of the tumor was observed in six out of seven cases. At the present time, four patients are still alive without evidence of disease. Slight acceleration of irradiation by the use of a concomitant electron boost is easily feasible and may provide an improvement in local control and therapeutic ratio of large cervical malignant masses in the neck.
让 - 戈迪诺研究所对7例伴有巨大颈部淋巴结转移的患者采用了一种特殊的加速照射方案进行治疗。采用常规钴 - 60放疗对颈部扩大区域进行预防性照射(5周内分25次给予50 Gy)。在钴照射野内,增加一个电子束野,将每日剂量从2 Gy提高到3 Gy(野中野技术中的弗莱彻野)。剂量增加仅限于淋巴结区域。由于两次照射之间没有间隔,受累区域在5周内分25次接受70 Gy照射,非临床受累区域在5周内分25次接受50 Gy照射。所有病例中,恶性肿块直径均超过5 cm。急性耐受性良好,在至少18个月的随访期内未观察到严重的晚期损伤。治疗结束时,7例患者中有6例肿瘤完全消失。目前,4例患者仍然存活,无疾病迹象。通过使用同步电子束增敏进行轻微的照射加速很容易实现,并且可能提高颈部巨大颈部恶性肿块的局部控制率和治疗比。