Sharp T, Bennett G W, Marsden C A, Tulloch I F
Regul Pept. 1984 Nov;9(4):305-15. doi: 10.1016/0167-0115(84)90083-1.
Thyrotrophin-releasing hormone (TRH) and its stable analogues CG3509 and RX77368 were injected directly into the nucleus accumbens, septum and striatum of the rat and locomotor activity was recorded. TRH (5-20 micrograms) caused a dose-dependent increase in locomotor activity when injected into the nucleus accumbens. TRH (20 micrograms) also increased locomotor activity after administration into the septum but not when put into the striatum. Both the TRH analogues (0.1 and 1.0 microgram) produced closely related increases in activity when injected into either the nucleus accumbens or septum but CG3509 was more potent with a longer lasting effect. Also, in contrast with TRH (20 micrograms), both TRH analogues stimulated locomotor activity when injected into the striatum at a dose of 1 microgram but the effect was less marked and delayed in onset compared to the nucleus accumbens and septum response. Dopamine (100 micrograms) injected into the accumbens or septum also produced significant increases in locomotor activity. The locomotor effects of the peptides are discussed in relation to a possible dopamine-mediated mechanism which contrasts with the actions of TRH and the analogues on barbiturate anaesthesia.
将促甲状腺激素释放激素（TRH）及其稳定类似物CG3509和RX77368直接注射到大鼠的伏隔核、隔区和纹状体中，并记录其运动活性。当将TRH（5 - 20微克）注射到伏隔核中时，会引起运动活性呈剂量依赖性增加。将TRH（20微克）注射到隔区后也会增加运动活性，但注射到纹状体中则不会。当将两种TRH类似物（0.1和1.0微克）注射到伏隔核或隔区时，都会产生密切相关的活性增加，但CG3509的效力更强，作用持续时间更长。此外，与TRH（20微克）不同，当以1微克的剂量将两种TRH类似物注射到纹状体中时，都会刺激运动活性，但与伏隔核和隔区的反应相比，其作用不太明显且起效延迟。将多巴胺（100微克）注射到伏隔核或隔区也会使运动活性显著增加。本文讨论了这些肽类对运动的影响与一种可能的多巴胺介导机制的关系，该机制与TRH及其类似物对巴比妥类麻醉的作用形成对比。
