Fernandez G, Castro J A
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):361-4.
Prolongation effects of promethazine on the pentobarbital sleeping time are not due to interactions of this drug with cytochrome P-450 or cytochrome c reductase or inhibition of drug metabolism because pentobarbital plasma levels in promethazine treated animals before awakening are not different than in controls. Results suggest additive effects of both drugs on the central nervous system. Those interactions do however play a role during in vitro studies.
异丙嗪对戊巴比妥睡眠时间的延长作用并非源于该药物与细胞色素P-450或细胞色素c还原酶的相互作用，也不是由于对药物代谢的抑制，因为在觉醒前接受异丙嗪治疗的动物中，戊巴比妥的血浆水平与对照组并无差异。结果表明两种药物对中枢神经系统具有相加作用。然而，这些相互作用在体外研究中确实发挥了作用。
