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γ-氨基丁酸与镇痛有关吗?

Is GABA involved in analgesia?

作者信息

Sethy V H, Bombardt P A

出版信息

Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):365-8.

PMID:644128
Abstract

The effect of morphine and naloxone on gamma-aminobutyric acid (GABA) concentration in discrete areas of the rat brain has been studied. Neither morphine nor naloxone had a significant effect on regional steady-state concentrations of GABA. The results have been discussed with respect to the role of GABA in pain and analgesia.

摘要

已经研究了吗啡和纳洛酮对大鼠脑离散区域中γ-氨基丁酸(GABA)浓度的影响。吗啡和纳洛酮对GABA的区域稳态浓度均无显著影响。已就GABA在疼痛和镇痛中的作用对结果进行了讨论。

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