Perrin J H, Field F P, Hansen D A, Mufson R A, Torosian G
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):373-6.
A peritoneal dialysate containing beta-cyclodextrin has been shown to accelerate the removal of intravenously administered phenobarbital in rats. It was found that high concentrations of beta-cyclodextrin were toxic to the animals in the single exchange technique employed. The renal toxicity was estimated by measuring blood urea nitrogen values in the rats following oral and intraperitoneal administration of the cyclic amylose.
含β-环糊精的腹膜透析液已被证明能加速大鼠体内静脉注射苯巴比妥的清除。发现在所采用的单次交换技术中，高浓度的β-环糊精对动物有毒性。通过测量大鼠口服和腹腔注射环状直链淀粉后的血尿素氮值来评估肾毒性。
