Demina A A, Parunina T M, Deviatkin N P, Martynov Iu V, Koroleva I S
Zh Mikrobiol Epidemiol Immunobiol. 1984 Nov(11):88-92.
The results of the study of the reactogenic and immunogenic properties of meningococcal polysaccharide A + C vaccine in the controlled epidemiological trial, with regard to variations depending on the initial immunological characteristics of vaccinees in terms of the levels of antibodies to the polysaccharides contained in the vaccine, are presented. The study was made on school children: 303 of them were immunized with the meningococcal vaccine under test, and 229 (controls) with adsorbed diphtheria-tetanus toxoid. This study revealed that the reactogenic properties of the preparation were more pronounced in those children whose blood sera had been found to contain no antibodies to polysaccharides A and C prior to immunization. The immunological properties were more pronounced with respect to polysaccharide A. The titer of antibodies to polysaccharide A was found to depend on the previous immunological status of the child, which was indicative of the booster effect produced by the vaccine. The data obtained in the study suggest that the evaluation of the reactogenic and immunogenic properties of newly developed prophylactic preparations should be made with due regard for the previous immunological status of vaccinees in respect to the antigens contained in the meningococcal vaccine under test.
本文展示了在对照流行病学试验中，关于A + C型脑膜炎球菌多糖疫苗的反应原性和免疫原性特性的研究结果，该结果取决于接种者针对疫苗中所含多糖的抗体水平的初始免疫特征差异。研究对象为学童：其中303人接种了受试脑膜炎球菌疫苗，229人（对照组）接种了吸附白喉 - 破伤风类毒素。该研究表明，对于那些在免疫前血清中未发现针对A和C多糖抗体的儿童，制剂的反应原性更为明显。免疫特性在多糖A方面更为显著。发现针对多糖A的抗体滴度取决于儿童先前的免疫状态，这表明疫苗产生了加强效应。该研究获得的数据表明，在评估新开发的预防性制剂的反应原性和免疫原性特性时，应充分考虑接种者针对受试脑膜炎球菌疫苗中所含抗原的先前免疫状态。
