Van Caillie-Bertrand M, Degenhart H J, Fernandes J
Acta Paediatr Scand. 1984 Nov;73(6):816-9. doi: 10.1111/j.1651-2227.1984.tb17781.x.
We investigated the selenium status of 5 infants while on nutritional support. After 4 weeks of parenteral nutrition a significant fall in plasma selenium concentrations was observed (mean +/- SD: 0.8 +/- 0.5 micrograms/dl; normal for this age: 3.6 +/- 0.9 micrograms/dl). In 1 infant the decline in selenium value occurred simultaneously with a transient rise in transaminases. A parallel but delayed decrease in red blood cell-glutathione peroxidase activity was seen in 3 patients. After reintroduction of enteral foods, the selenium levels increased progressively to and reached control values after 6 weeks, 4 and 5 months respectively in 3 patients, suggesting that the selenium requirement on TPN was not met. We consider it essential to provide longterm TPN patients with physiological amounts of selenium in order to prevent the progressive development of a deficiency state.
我们调查了5名接受营养支持的婴儿的硒状态。肠外营养4周后，观察到血浆硒浓度显著下降（均值±标准差：0.8±0.5微克/分升；该年龄正常范围：3.6±0.9微克/分升）。1名婴儿的硒值下降同时伴有转氨酶短暂升高。3名患者出现红细胞谷胱甘肽过氧化物酶活性平行但延迟下降。重新引入肠内食物后，3名患者的硒水平分别在6周、4个月和5个月后逐渐升高并达到对照值，提示全胃肠外营养时硒需求未得到满足。我们认为有必要为长期接受全胃肠外营养的患者提供生理剂量的硒，以防止缺乏状态的逐步发展。
