Lothrop C D, Tamas P M, Fadok V A
Am J Vet Res. 1984 Nov;45(11):2310-3.
A canine and feline pituitary-thyroid function test based on thyrotropin-releasing hormone (TRH) stimulation of endogenous thyrotropin is described. Serum thyroxine is measured before and after stimulation with TRH. A positive response to TRH indicated a functionally intact pituitary-thyroid axis. At TRH doses of 0.002 to 10.0 mg/kg of body weight, dose response of serum thyroxine to TRH stimulation was determined. Increasing the dose of TRH increased the duration, but not the magnitude, of thyroxine stimulation. At TRH doses greater than 0.1 mg/kg, drug side effects were salivation, defecation, urination, vomition, miosis, tachycardia, and tachypnea. A useful procedure for pituitary-thyroid function testing was serum thyroxine measurement before and 6 hours after TRH (0.1 mg/kg) stimulation.
本文描述了一种基于促甲状腺激素释放激素（TRH）刺激内源性促甲状腺激素的犬猫垂体-甲状腺功能测试。在TRH刺激前后测量血清甲状腺素。对TRH的阳性反应表明垂体-甲状腺轴功能完整。在TRH剂量为0.002至10.0mg/kg体重的情况下，测定血清甲状腺素对TRH刺激的剂量反应。增加TRH剂量可延长甲状腺素刺激的持续时间，但不增加其幅度。当TRH剂量大于0.1mg/kg时，药物副作用包括流涎、排便、排尿、呕吐、瞳孔缩小、心动过速和呼吸急促。一种用于垂体-甲状腺功能测试的有用方法是在TRH（0.1mg/kg）刺激前和刺激后6小时测量血清甲状腺素。
