Blickle J F, Schlienger J L, De Laharpe F, Stephan F
Ann Endocrinol (Paris). 1984;45(3):161-4.
The effect of bromocriptine on growth hormone (GH) responses to TRH was studied in 14 insulin-dependent diabetics. The effect of this dopaminomimetic agent was inconstant. In the 6 patients with inadequate responses of GH to TRH, bromocriptine inhibited this response. Inversely, it appeared capable of stimulating a GH response in certain non-responders. The could suggest the existence of disturbances of dopaminergic control of GH secretion in diabetics, but the lack of reproducibility of responses of GH to TRH makes this an uncertain conclusion.
在14例胰岛素依赖型糖尿病患者中研究了溴隐亭对生长激素(GH)对促甲状腺激素释放激素(TRH)反应的影响。这种拟多巴胺药物的作用并不稳定。在6例GH对TRH反应不足的患者中,溴隐亭抑制了这种反应。相反,在某些无反应者中,它似乎能够刺激GH反应。这可能提示糖尿病患者存在GH分泌多巴胺能控制的紊乱,但GH对TRH反应缺乏可重复性使得这一结论不确定。