[二硫苏糖醇和硫氧还蛋白对大鼠肝脏中氨甲酰磷酸合成酶-I的体外激活作用]
[In vitro activation by dithiothreitol and thioredoxins of carbamyl phosphate synthetase-I in rat liver].
作者信息
Gautier C, Habechi Z, Balangé A P, Vaillant R
出版信息
C R Acad Sci III. 1984;299(20):849-52.
PMID:6441619
Abstract
Carbamyl phosphate synthetase-I (CPS-I; EC 6.3.4.16), a mitochondrial enzyme of the urea-cycle, was studied in deactivated extracts of rat liver. It has been found to be activated in vitro by dithiothreitol (DTT) and Mg2+ ions. After reduction by DTT, thioredoxins, isolated from rat liver, were able to activate CPS-I by 468%.
摘要
氨甲酰磷酸合成酶-I（CPS-I；EC 6.3.4.16）是尿素循环中的一种线粒体酶，在大鼠肝脏的失活提取物中进行了研究。已发现它在体外可被二硫苏糖醇（DTT）和镁离子激活。经DTT还原后，从大鼠肝脏分离出的硫氧还蛋白能够使CPS-I的活性提高468%。
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