Naspitz C K
J Asthma. 1984;21(6):451-60. doi: 10.3109/02770908409083226.
The function of the cells involved in the genesis of bronchial asthma is calcium dependent. The "Ca2+ hypothesis of asthma" suggests that calcium channel blocking agents may have a beneficial effect in asthma. The clinical trials with the available classic calcium antagonists in childhood asthma are very few and their clinical application remains to be determined. Sodium cromoglycate and ketotifen, which have been in clinical use for many years, can be considered as calcium channel blockers and seem to have a significant role in the prophylaxis of bronchial asthma.
参与支气管哮喘发病的细胞功能依赖于钙。“哮喘的钙假说”表明钙通道阻滞剂可能对哮喘有有益作用。针对儿童哮喘使用现有经典钙拮抗剂的临床试验非常少，其临床应用仍有待确定。已临床使用多年的色甘酸钠和酮替芬可被视为钙通道阻滞剂，似乎在支气管哮喘的预防中具有重要作用。
