Szökö E, Kalász H, Kerecsen L, Magyar K
Pol J Pharmacol Pharm. 1984 Jul-Aug;36(4):413-21.
14C-Deprenyl binding to serum proteins has been investigated using equilibrium dialysis and gel chromatography. Experiments in the equilibrium dialysis cells were performed both for binding of deprenyl to the serum proteins and the dissociation of the previously serum bound deprenyl. Comparative investigations were made with substance E, this reference compound showed reversible binding contrary to deprenyl that remained partially irreversibly bound to the serum proteins even in such conditions when substance E became totally released.
已使用平衡透析和凝胶色谱法研究了14C-司来吉兰与血清蛋白的结合情况。在平衡透析池中进行了司来吉兰与血清蛋白结合以及先前与血清结合的司来吉兰解离的实验。用物质E进行了对比研究，该参考化合物显示出可逆结合，与司来吉兰相反，即使在物质E完全释放的情况下，司来吉兰仍部分不可逆地结合于血清蛋白。
