Rosen E M, Cassady J R, Frantz C N, Kretschmar C, Levey R, Vawter G, Sallan S E
Radiother Oncol. 1984 Oct;2(3):189-200. doi: 10.1016/s0167-8140(84)80059-6.
One hundred and thirty-six patients with neuroblastoma have been treated at our center from 1970 to 1982, using various combinations of surgery, radiation therapy, and chemotherapy. Choice of therapy was individualized but depended primarily on age and stage. The overall disease-free survival was 60% (minimum follow-up of one year). Patients with stage I disease and younger patients with stage II disease usually received less intensive therapy and fared extremely well (100% survival). Patients with stage III disease and older patients with stage II disease also did extremely well (survival of 85% and 90%, respectively). These patients may have benefited from intensive treatment with all three modalities. Patients under one year of age with stage IV neuroblastoma were treated with surgery and multiagent chemotherapy, and 92% (11/12) survived free of disease. Patients over one year old with stage IV disease represented the only group for which therapy was unsuccessful (10% survival). With combination approaches and with more effective multiagent chemotherapeutic regimens, a real impact on the survival of older stage II patients, stage III patients, and younger stage IV patients appears to have been made. However, older stage IV patients are rarely cured with conventional therapy, and better approaches will be needed for this group.
1970年至1982年期间，我们中心共治疗了136例神经母细胞瘤患者，采用了手术、放射治疗和化疗的各种联合治疗方法。治疗方案的选择是个体化的，但主要取决于年龄和分期。总体无病生存率为60%（最短随访一年）。I期疾病患者和年龄较小的II期疾病患者通常接受的治疗强度较低，预后非常好（生存率为100%）。III期疾病患者和年龄较大的II期疾病患者预后也非常好（生存率分别为85%和90%）。这些患者可能从三种治疗方式的强化治疗中获益。1岁以下的IV期神经母细胞瘤患者接受了手术和多药化疗，92%（11/12）的患者无病存活。1岁以上的IV期疾病患者是唯一治疗失败的组（生存率为10%）。通过联合治疗方法和更有效的多药化疗方案，似乎对年龄较大的II期患者、III期患者和较年轻的IV期患者的生存率产生了实际影响。然而，年龄较大的IV期患者很少能通过传统治疗治愈，这组患者需要更好的治疗方法。
