McDonald T P
Scand J Haematol. 1978 Mar;20(3):213-20. doi: 10.1111/j.1600-0609.1978.tb02450.x.
Platelet production rates were studied in hypoxic, red blood cell (RBC) transfused, and normal mice. In addition, platelet depletion was induced in some of the mice by injection of rabbit anti-mouse platelet serum (RAMPS) to stimulate platelet production. Hypoxia alone caused an increase in haematocrit and platelet count at 1-3 d, followed by a decrease in platelet counts to below normal values at 6-7 d. On the otherhand, RBC transfusion caused increase haematocrit and decreased platelet count of mice at 1-4 d, with a return of platelet counts to normal by 5-6 d. Normal mice and mice transfused with RBC responded to platelet depletion with rebound-thrombocytosis with maximum platelet production 3-5 d later and elevated platelet counts on days 5-6. However, platelet production in platelet-depleted mice exposed to hypoxia was less marked, and platelet counts did not reach normal levels. The data are consistent with the hypothesis that hypoxia causes thrombocytopenia by stem cell competition between erythroid and megakaryocytic cell lines and/or inhibition of thrombopoietin production.
在低氧、输注红细胞（RBC）的小鼠以及正常小鼠中研究了血小板生成率。此外，通过注射兔抗小鼠血小板血清（RAMPS）诱导部分小鼠血小板减少，以刺激血小板生成。单独低氧在1 - 3天时导致血细胞比容和血小板计数增加，随后在6 - 7天时血小板计数降至正常水平以下。另一方面，输注RBC在1 - 4天时导致小鼠血细胞比容增加和血小板计数减少，到5 - 6天时血小板计数恢复正常。正常小鼠和输注RBC的小鼠对血小板减少的反应是反弹性血小板增多，最大血小板生成在3 - 5天后出现，且在第5 - 6天时血小板计数升高。然而，暴露于低氧环境的血小板减少小鼠的血小板生成不太明显，血小板计数未达到正常水平。这些数据与以下假设一致，即低氧通过红系和巨核细胞系之间的干细胞竞争和/或血小板生成素产生的抑制导致血小板减少。
