Mansuri S M, Raval J D, Girdhar A O, Gandhi T P
Indian J Physiol Pharmacol. 1984 Oct-Dec;28(4):315-8.
Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.
研究了卡马西平（CA）和丙戊酸钠（SV）对中枢神经系统和神经肌肉接头的作用。腹腔注射CA和SV对大鼠既无镇痛作用也无体温降低作用，对小鼠戊巴比妥睡眠时间也无影响。这两种药物对青蛙的耻骨肌没有作用，也不改变其对乙酰胆碱的反应。CA和SV均可使大鼠膈肌和猫腓肠肌间接诱发收缩产生剂量相关的降低，而对直接诱发反应的改变不大。这种作用可能是由于它们的局部麻醉特性，这在豚鼠浸润试验中得到了观察。
