替莫西林：对734株选定临床分离株的体外活性，包括产β-内酰胺酶菌株。

Temocillin: in vitro activity against 734 selected clinical isolates, including beta-lactamase-producing strains.

作者信息

Fuchs P C, Barry A L, Jones R N, Thornsberry C

出版信息

Diagn Microbiol Infect Dis. 1984 Jan;2(1):55-63. doi: 10.1016/0732-8893(84)90023-3.

Abstract

The in vitro activity of temocillin against 734 clinical isolates was tested by broth microdilution. Good activity was demonstrated against Enterobacteriaceae and both beta-lactamase-positive and -negative strains of Haemophilus influenzae and Neisseria gonorrhoeae. There was little to no activity against gram-positive cocci and nonfermenting gram-negative bacilli. Bactericidal activity and effect of inoculum size on temocillin activity were comparable to that of ticarcillin. Temocillin was stable to commonly encountered beta-lactamases and significantly inhibited Richmond-Sykes type 1 enzymes of Enterobacter cloacae.

摘要

采用肉汤微量稀释法检测替莫西林对734株临床分离菌的体外活性。结果表明，替莫西林对肠杆菌科细菌以及流感嗜血杆菌和淋病奈瑟菌的β-内酰胺酶阳性及阴性菌株均有良好活性。对革兰氏阳性球菌和非发酵革兰氏阴性杆菌几乎没有活性。替莫西林的杀菌活性以及接种量对其活性的影响与替卡西林相当。替莫西林对常见的β-内酰胺酶稳定，并能显著抑制阴沟肠杆菌的里士满-赛克斯1型酶。