Nadaud D, Simon H, Herman J P, Le Moal M
Physiol Behav. 1984 Dec;33(6):879-87. doi: 10.1016/0031-9384(84)90222-1.
Four experiments examined the neural substrates for the aphagia and adipsia syndrome resulting from damage of the ventral tegmental region. Radiofrequency (RF) lesions at the level of the mesencephalon in rats showed that the most effective site for producing aphagia and adipsia was in an intermediate zone between the substantia nigra and the ventral tegmental area. Injection of the neurotoxin 6-hydroxydopamine (6-OHDA) into this intermediate zone led to a less severe feeding deficit, suggesting that both dopaminergic and non-dopaminergic neurons are involved in the mesencephalic aphagic syndrome. As the lemniscus trigeminalis was destroyed after the RF lesion of the intermediate zone, the hypothesis of trigeminal projection involvement was tested by lesioning (RF) the sensory trigeminal nucleus. These rats were aphagic but they recovered and their deficit was less severe than after RF lesion of the mesencephalic intermediate zone. In the last experiment, a combined 6-OHDA lesion of the mesencephalic intermediate zone and RF lesion of the trigeminal sensory nucleus led to a more severe deficit in feeding behavior than either lesion alone. These results further demonstrate that feeding behavior is under the control of a complex system involving several neural pathways.
四项实验研究了腹侧被盖区受损导致的摄食不能和饮水不能综合征的神经基质。对大鼠中脑水平进行射频（RF）损伤显示，导致摄食不能和饮水不能的最有效部位是黑质和腹侧被盖区之间的中间带。向该中间带注射神经毒素6-羟基多巴胺（6-OHDA）导致的摄食缺陷较轻，这表明多巴胺能和非多巴胺能神经元均参与中脑摄食不能综合征。由于在中间带进行射频损伤后三叉神经丘系被破坏，通过损伤（射频）感觉三叉神经核来检验三叉神经投射参与的假说。这些大鼠出现摄食不能，但恢复了，且其缺陷比中脑中间带射频损伤后要轻。在最后一项实验中，中脑中间带联合6-OHDA损伤和三叉神经感觉核射频损伤导致的摄食行为缺陷比单独任何一种损伤都更严重。这些结果进一步证明，摄食行为受一个涉及多条神经通路的复杂系统控制。
