Hejzlar M, Sedmidubský V, Procházková A, Dvorský V, Stastná L, Paroubek M, Kotasová M, Puchmayerová M, Silarová J, Gleichová L
J Hyg Epidemiol Microbiol Immunol. 1984;29(3):311-5.
As a part of preclinical trials of 2,996 clinical isolates from three larger hospitals in Prague were qualitatively and quantitatively assayed for in vitro sensitivity to ceftazidime. In gramnegative bacteria the incidence of resistance to ceftazidime in strain of Enterobacter, Serratia Proteus and Pseudomonas species ranged from 4% to 6% of strains. In grampositive bacteria only strains of enterococci, listeriae and anaerobic bacteria are excluded from the action of this broad-spectrum antibiotic. According to present experiences the antipseudomonal activity of ceftazidime is approximately the same as that of cefsulodine and cefoperazone. Alarmingly, one of the Pseudomonas aeruginosa isolates was found to show a distinct multiresistance to all available lactam, aminoglycoside and broad-spectrum antimicrobials, including ceftazidime.
作为临床前试验的一部分，对来自布拉格三家较大医院的2996株临床分离菌进行了头孢他啶体外敏感性的定性和定量测定。在革兰氏阴性菌中，肠杆菌属、沙雷氏菌属、变形杆菌属和假单胞菌属菌株对头孢他啶的耐药发生率在菌株的4%至6%之间。在革兰氏阳性菌中，只有肠球菌属、李斯特菌属和厌氧菌菌株不受这种广谱抗生素作用的影响。根据目前的经验，头孢他啶的抗假单胞菌活性与头孢磺啶和头孢哌酮大致相同。令人担忧的是，发现一株铜绿假单胞菌分离株对所有可用的内酰胺类、氨基糖苷类和广谱抗菌药物，包括头孢他啶，表现出明显的多重耐药性。
