Brown F, Dougan G, Snary D
Wellcome Biotechnology Limited, Beckenham, Kent, UK.
Microbiol Sci. 1984 Aug;1(5):123-7.
Determinants of important protective antigens from a variety of viral, bacterial and parasite pathogens have been successfully cloned and expressed in novel hosts using recombinant DNA techniques. The use of these cloned determinants in the development of new vaccines, including immunologically defined subunit vaccines, genetically defined live attenuated vaccines, and synthetic peptide vaccines is described.
利用重组DNA技术，已成功克隆了来自多种病毒、细菌和寄生虫病原体的重要保护性抗原的决定簇，并在新的宿主中进行了表达。本文描述了这些克隆的决定簇在新型疫苗开发中的应用，包括免疫定义的亚单位疫苗、基因定义的减毒活疫苗和合成肽疫苗。
