Johnson D, Kubic P, Levitt C
Am J Dis Child. 1980 Feb;134(2):161-4.
A recently introduced rodenticide containing N-3-pyridylmethyl N'-p-nitrophenyl urea (PNU), Vacor, was accidently ingested by a 25-month-old child, resulting in acute vomiting, lethargy, seizures, and hypoglycemia, as well as chronic evidence of autonomic and peripheral neuropathy and glucose intolerance. Treatment with niacinamide (nicotinamide), may have been of benefit since all problems were resolved within three months of ingestion. This agent (PNU) is remarkably similar chemically and toxicologically to alloxan and streptozocin, both potent beta-cell toxins. These similarities are not only important in regard to the antodite for PNU, but they also suggest that the toxin m,y cause long-term endocrinologic, neurlogic, and oncologic problems.
一种最近引入的含有N-3-吡啶基甲基-N'-对硝基苯基脲（PNU）的灭鼠剂Vacor，被一名25个月大的儿童意外摄入，导致急性呕吐、嗜睡、癫痫发作和低血糖，以及自主神经和周围神经病变及葡萄糖耐量异常的慢性症状。使用烟酰胺进行治疗可能有益，因为所有问题在摄入后三个月内都得到了解决。这种药剂（PNU）在化学和毒理学上与两种强效β细胞毒素——四氧嘧啶和链脲佐菌素非常相似。这些相似性不仅在PNU解毒剂方面很重要，而且还表明这种毒素可能会导致长期的内分泌、神经和肿瘤问题。
