• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Comparative study of x-ray and UV induced cytotoxicity, DNA repair, and mutagenesis in Down's syndrome and normal fibroblasts.

作者信息

Yotti L P, Glover T W, Trosko J E, Segal D J

出版信息

Pediatr Res. 1980 Feb;14(2):88-92. doi: 10.1203/00006450-198002000-00003.

DOI:10.1203/00006450-198002000-00003
PMID:6444711
Abstract

Utilizing six age-matched human fibroblast cell strains (three normal and three Down's syndrome) cytotoxicity, DNA repair, and X-ray mutagenesis were measured. There was no significant difference in the colony-forming ability after ultraviolet (UV) or X-irradiation between normal and Down's fibroblasts. Similarly, UV-induced unscheduled DNA synthesis was not significantly different between normal and Down's cells. Finally, a comparison between the spontaneous and X-ray induced mutation frequency at the hypoxanthine-guanine phosphoribosyl transferase locus demonstrated no difference between the two cell types (normal and Down's).

摘要

相似文献

1
Comparative study of x-ray and UV induced cytotoxicity, DNA repair, and mutagenesis in Down's syndrome and normal fibroblasts.
Pediatr Res. 1980 Feb;14(2):88-92. doi: 10.1203/00006450-198002000-00003.
2
Radiation sensitivity of Down's syndrome fibroblasts might be due to overexpressed Cu/Zn-superoxide dismutase (EC 1.15.1.1).唐氏综合征成纤维细胞的辐射敏感性可能归因于过度表达的铜/锌超氧化物歧化酶（EC 1.15.1.1）。
Eur J Cell Biol. 1989 Feb;48(1):79-87.
3
DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome.唐氏综合征患者白细胞中DNA修复以及X射线和紫外线诱导的染色体畸变频率
Ann Hum Genet. 1976 Jan;39(3):293-303. doi: 10.1111/j.1469-1809.1976.tb00133.x.
4
The repair of X-ray induced chromosomal damage in trisomy 2-and normal diploid lymphocytes.
Cancer Res. 1977 Jan;37(1):52-8.
5
[Radioresistant DNA synthesis in the fibroblasts of a Down's syndrome patient].[唐氏综合征患者成纤维细胞中的抗辐射DNA合成]
Tsitologiia. 1985 May;27(5):582-6.
6
Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation.UVA、UVB和X射线辐射后成纤维细胞中延迟突变和染色体不稳定性的诱导。
Cancer Res. 2003 Apr 1;63(7):1464-9.
7
Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.DNA聚合酶η的过量产生不会提高二倍体人类成纤维细胞的自发突变率。
DNA Repair (Amst). 2005 Jun 8;4(6):714-24. doi: 10.1016/j.dnarep.2005.04.002.
8
Telomerase-immortalized human fibroblasts retain UV-induced mutagenesis and p53-mediated DNA damage responses.端粒酶永生化的人成纤维细胞保留紫外线诱导的诱变作用和p53介导的DNA损伤反应。
DNA Repair (Amst). 2006 Jan 5;5(1):61-70. doi: 10.1016/j.dnarep.2005.07.005. Epub 2005 Sep 1.
9
Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li-Fraumeni syndrome fibroblast strains heterozygous for TP53 mutations.异常的p21WAF1依赖性生长停滞作为Li-Fraumeni综合征成纤维细胞株（杂合TP53突变）对紫外线细胞毒性异常抗性的可能机制。
Oncogene. 1998 Aug 6;17(5):533-43. doi: 10.1038/sj.onc.1202271.
10
[X-ray-induced DNA degradation in Aspergillus nidulans cells. Comparative analysis of UV- and Xray-induced DNa degradation].[构巢曲霉细胞中X射线诱导的DNA降解。紫外线和X射线诱导的DNA降解的比较分析]
Genetika. 1980;16(7):1189-98.

引用本文的文献

1
Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.布卢姆综合征成纤维细胞中自发突变率升高。
Proc Natl Acad Sci U S A. 1981 May;78(5):3133-7. doi: 10.1073/pnas.78.5.3133.
2
Chromosomal radiosensitivity of Down syndrome lymphocytes at different stages of the cell cycle.
Hum Genet. 1988 Jan;78(1):71-5. doi: 10.1007/BF00291238.