人胎儿血浆中低密度脂蛋白胆固醇与硫酸脱氢表雄酮之间的负相关关系。

Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma.

作者信息

Parker C R, Simpson E R, Bilheimer D W, Leveno K, Carr B R, MacDonald P C

出版信息

Science. 1980 May 2;208(4443):512-4. doi: 10.1126/science.6445079.

Abstract

A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.

摘要

在脐带血浆中发现，硫酸脱氢表雄酮浓度与低密度脂蛋白（LDL）胆固醇浓度呈显著负相关，但与高密度脂蛋白胆固醇或极低密度脂蛋白胆固醇浓度无关。硫酸脱氢表雄酮是人类胎儿肾上腺的主要分泌产物，也是胎盘雌激素生成的主要前体。数据表明，胎儿血浆中LDL胆固醇的浓度受胎儿肾上腺用于类固醇生成的LDL胆固醇利用率影响，不一定与高胆固醇血症或其他脂蛋白紊乱的遗传易感性有关。