Kittler L, Hradecná Z, Sühnel J
Biochim Biophys Acta. 1980 Apr 30;607(2):215-20. doi: 10.1016/0005-2787(80)90074-x.
The combined action of 365 nm ultraviolet light and xanthotoxin or angelicin inhibits the injection of phage lambda into the host. For both furocoumarin derivatives the inhibition of injection is discussed in terms of photochemically induced cross-linking of the DNA inside the phage heads; Cross-linking of DNA has previously been described for xanthotoxin (Musajo, L. and Rodighiero, G. (1972) in Photophysiology (Giese, A.C., ed.), Vol. VII, pp. 115-147, Academic Press, New York and Scott, B.R., Pathak, M.A. and Mohn, G.R. (1976) Mutation Res. 39, 30-74) but not for angelicin. The electronic structures in the first excited states calculated by means of quantum chemistry according to the Pariser-Parr-Pople method are very similar for xanthotoxin, psoralen and angelicin. Hence angelicin should be capable of acting bifunctionally like xanthotoxin, but for sterical reasons such reaction should be possible only for the folded DNA, as in phage heads, but not for diluted aqueous solution of DNA.
365纳米紫外线与补骨脂素或白芷素的联合作用可抑制噬菌体λ注入宿主。对于这两种呋喃香豆素衍生物，注入抑制作用是根据光化学诱导噬菌体头部内DNA交联来讨论的；先前已描述过补骨脂素的DNA交联情况（穆萨乔，L.和罗迪吉耶罗，G.（1972年）载于《光生理学》（吉斯，A.C.编），第七卷，第115 - 147页，学术出版社，纽约；以及斯科特，B.R.、帕塔克，M.A.和莫恩，G.R.（1976年）《突变研究》39卷，第30 - 74页），但未提及白芷素的。根据帕里泽 - 帕尔 - 波普尔方法通过量子化学计算得出的补骨脂素、补骨脂内酯和白芷素第一激发态的电子结构非常相似。因此，白芷素应能够像补骨脂素一样发挥双功能作用，但由于空间位阻原因，这种反应仅在如噬菌体头部那样折叠的DNA中才有可能发生，而在稀释的DNA水溶液中则不会发生。
