Phillipou G, Frith R G
Clin Chim Acta. 1980 Apr 25;103(2):129-33. doi: 10.1016/0009-8981(80)90204-1.
Investigation of various derivatives (O-methyloxime, trifluoroenol acetate and t-butyldimethylsilyl enol ether) coupled with the efficient preparation of a trideuterated analogue of medroxyprogesterone acetate, has allowed the development of a rapid and accurate assay for its quantitation in plasma by isotope dilution gas chromatography/mass spectrometry. High oral doses (2.8 g weekly) of medroxyprogesterone acetate are shown to lead consistently to plasma levels of less than 16 ng.ml-1.
对各种衍生物（O-甲基肟、三氟烯醇乙酸酯和叔丁基二甲基甲硅烷基烯醇醚）进行研究，并结合高效制备醋酸甲羟孕酮的三氘代类似物，从而开发出一种通过同位素稀释气相色谱/质谱法快速准确地测定血浆中该物质含量的方法。研究表明，每周口服高剂量（2.8克）的醋酸甲羟孕酮会持续导致血浆水平低于16纳克/毫升。
