包裹于脂质体中的新制癌菌素的抗肿瘤作用。

Antitumor effect of neocarzinostatin entrapped in liposomes.

作者信息

Shinozawa S, Araki Y, Oda T

出版信息

Gan. 1980 Feb;71(1):107-11.

Abstract

Antitumor effect against mouse Ehrlich ascites carcinoma was examined on Neocarzinostatin (NCS) entrapped in sonicated liposomes (neutral and negatively or positively charged forms) in comparison with free NCS. In the intraperitoneal inoculation-intraperitoneal medication system, NSC entrapped in negatively charged liposomes, which was most unstable in aqueous solution, showed statistically significant prolongation of survival days in mice compared to free NCS. In contrast, survival days of the animals given NCS entrapped in positively charged liposomes were shorter than those of the corresponding groups given free NCS. On the other hand in the intraperitoneal inoculation-intravenous medication system, survival days were not prolonged markedly by administration of free NCS, BUT WHEN NCS was entrapped in positively charged or neutral liposomes, prolongation of survival was apparent compared to the corresponding groups given free NCS. The most marked effect was seen when NCS was entrapped in positively charged liposomes, which show the best stability in aqueous solution.

摘要

研究了包裹于经超声处理的脂质体（中性、带负电荷或带正电荷形式）中的新制癌菌素（NCS）对小鼠艾氏腹水癌的抗肿瘤作用，并与游离NCS进行比较。在腹腔接种-腹腔给药系统中，包裹于带负电荷脂质体中的NSC在水溶液中最不稳定，与游离NCS相比，其在小鼠体内的存活天数有统计学意义的延长。相反，给予包裹于带正电荷脂质体中的NCS的动物的存活天数比给予相应游离NCS组的动物短。另一方面，在腹腔接种-静脉给药系统中，游离NCS给药并未显著延长存活天数，但当NCS包裹于带正电荷或中性脂质体中时，与给予游离NCS的相应组相比，存活天数明显延长。当NCS包裹于在水溶液中稳定性最佳的带正电荷脂质体中时，效果最为显著。

相似文献

1

Antitumor effect of neocarzinostatin entrapped in liposomes.包裹于脂质体中的新制癌菌素的抗肿瘤作用。

Gan. 1980 Feb;71(1):107-11.

2

Antitumor effect of neocarzinostatin entrapped in neutral, negatively and positively charged liposomes against Ehrlich solid carcinoma.包裹于中性、带负电荷和带正电荷脂质体中的新制癌菌素对艾氏实体癌的抗肿瘤作用。

Res Commun Chem Pathol Pharmacol. 1980 Oct;30(1):181-4.

3

Tissue distribution and antitumor effect of liposome-entrapped doxorubicin (adriamycin) in Ehrlich solid tumor-bearing mouse.

Acta Med Okayama. 1981 Dec;35(6):395-405. doi: 10.18926/AMO/31258.

4

[Effect of monoclonal antibody-neocarzinostatin conjugate for gastric cancer with peritoneal dissemination--comparison between early and late administration].

Gan To Kagaku Ryoho. 2001 Oct;28(11):1508-10.

5

Efficacy of two-route chemotherapy using intraperitoneal neocarzinostatin and its antidote, intravenous tiopronin, for peritoneally disseminated tumors in mice.使用腹腔注射新制癌菌素及其解毒剂静脉注射硫普罗宁的双途径化疗对小鼠腹膜播散性肿瘤的疗效。

Jpn J Cancer Res. 1989 Mar;80(3):283-9. doi: 10.1111/j.1349-7006.1989.tb02306.x.

6

In vitro and in vivo studies with anionic sulfatide-liposomes containing adriamycin.

Anticancer Res. 1986 Nov-Dec;6(6):1287-90.

7

[Use of arterial infusion of neocarzinostatin with or without combination chemotherapy as a treatment of carcinoma of the prostate].[使用新制癌菌素动脉灌注联合或不联合化疗治疗前列腺癌]

Gan To Kagaku Ryoho. 1986 Jul;13(7):2325-30.

8

Effect of liposome-encapsulated quercetin on DNA synthesis, lactate production, and cyclic adenosine 3':5'-monophosphate level in Ehrlich ascites tumor cells.脂质体包裹的槲皮素对艾氏腹水瘤细胞DNA合成、乳酸生成及环磷酸腺苷水平的影响

Cancer Res. 1980 Apr;40(4):1344-50.

9

In vivo antitumor activity of neocarzinostatin (NCS)-tumor antibody conjugate against a transplantable human leukemia cell line (BALL-1).新制癌菌素（NCS）-肿瘤抗体偶联物对可移植性人白血病细胞系（BALL-1）的体内抗肿瘤活性。

Jpn J Clin Oncol. 1983 Jun;13(2):425-33.

10

[Clinical evaluation of neocarzinostatin in digestive system cancer. 2. Clinical studies on the administration of neocarzinostatin in advanced and recurrent carcinoma of the pancreas].[新制癌菌素在消化系统癌症中的临床评估。2. 新制癌菌素用于晚期及复发性胰腺癌的临床研究]

Gan To Kagaku Ryoho. 1983 Aug;10(8):1872-7.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。