Shinozawa S, Araki Y, Oda T
Gan. 1980 Feb;71(1):107-11.
Antitumor effect against mouse Ehrlich ascites carcinoma was examined on Neocarzinostatin (NCS) entrapped in sonicated liposomes (neutral and negatively or positively charged forms) in comparison with free NCS. In the intraperitoneal inoculation-intraperitoneal medication system, NSC entrapped in negatively charged liposomes, which was most unstable in aqueous solution, showed statistically significant prolongation of survival days in mice compared to free NCS. In contrast, survival days of the animals given NCS entrapped in positively charged liposomes were shorter than those of the corresponding groups given free NCS. On the other hand in the intraperitoneal inoculation-intravenous medication system, survival days were not prolonged markedly by administration of free NCS, BUT WHEN NCS was entrapped in positively charged or neutral liposomes, prolongation of survival was apparent compared to the corresponding groups given free NCS. The most marked effect was seen when NCS was entrapped in positively charged liposomes, which show the best stability in aqueous solution.
研究了包裹于经超声处理的脂质体（中性、带负电荷或带正电荷形式）中的新制癌菌素（NCS）对小鼠艾氏腹水癌的抗肿瘤作用，并与游离NCS进行比较。在腹腔接种-腹腔给药系统中，包裹于带负电荷脂质体中的NSC在水溶液中最不稳定，与游离NCS相比，其在小鼠体内的存活天数有统计学意义的延长。相反，给予包裹于带正电荷脂质体中的NCS的动物的存活天数比给予相应游离NCS组的动物短。另一方面，在腹腔接种-静脉给药系统中，游离NCS给药并未显著延长存活天数，但当NCS包裹于带正电荷或中性脂质体中时，与给予游离NCS的相应组相比，存活天数明显延长。当NCS包裹于在水溶液中稳定性最佳的带正电荷脂质体中时，效果最为显著。
