鼠伤寒沙门氏菌的吡啶核苷酸循环：烟酰胺腺嘌呤二核苷酸的体内循环利用
Pyridine nucleotide cycle of Salmonella typhimurium: in vivo recycling of nicotinamide adenine dinucleotide.
作者信息
Foster J W, Baskowsky-Foster A M
出版信息
J Bacteriol. 1980 Jun;142(3):1032-5. doi: 10.1128/jb.142.3.1032-1035.1980.
Abstract
The relative contribution of the two known pyridine nucleotide cycles of Salmonella typhimurium towards the intracellular recycling of nicotinamide adenine dinucleotide was determined. The results indicate that intracellular nicotinamide adenine dinucleotide is recycled by both the four-membered pyridine nucleotide cycle (PNC IV) and the six-membered pyridine nucleotide cycle (PNC VI) with a relative contribution of 60 to 69% and 31 to 40%, respectively. These studies also revealed a nicotinic acid mononucleotide-degradative activity which converts nicotinic acid mononucleotide to nicotinic acid. This represents the first demonstration of a functional PNC IV pathway in S. typhimurium.
摘要
测定了鼠伤寒沙门氏菌两个已知的吡啶核苷酸循环对烟酰胺腺嘌呤二核苷酸细胞内再循环的相对贡献。结果表明，细胞内烟酰胺腺嘌呤二核苷酸通过四元吡啶核苷酸循环（PNC IV）和六元吡啶核苷酸循环（PNC VI）进行再循环，相对贡献分别为60%至69%和31%至40%。这些研究还揭示了一种将烟酸单核苷酸转化为烟酸的烟酸单核苷酸降解活性。这是首次在鼠伤寒沙门氏菌中证明功能性PNC IV途径。
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