大肠杆菌中6-氨基烟酸的代谢
Metabolism of 6-aminonicotinic acid in Escherichia coli.
作者信息
Cobb J R, Pearcy S C, Gholson R K
出版信息
J Bacteriol. 1977 Sep;131(3):789-94. doi: 10.1128/jb.131.3.789-794.1977.
Abstract
A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotide cycle. It is concluded that 6-aminonicotinamide and 6-aminonicotinic acid probably exert at least a portion of their bacteriostatic effects by being metabolized, by the enzymes of the pyridine nucleotide cycle, to 6-aminonicotinamide adenine dinucleotide and 6-aminonicotinamide adenine dinucleotide phosphate. These compounds are not electron acceptors and are known inhibitors of some pyridine nucleotide-linked dehydrogenases.
摘要
大肠杆菌nadB pncA双突变体的对数生长后期培养物摄取了6-[7-¹⁴C]氨基烟酸并排泄出6-[¹⁴C]氨基烟酰胺。该突变体还在细胞内积累了几种放射性化合物，初步鉴定为吡啶核苷酸循环中化合物的6-氨基类似物。结论是，6-氨基烟酰胺和6-氨基烟酸可能至少部分地通过被吡啶核苷酸循环的酶代谢为6-氨基烟酰胺腺嘌呤二核苷酸和6-氨基烟酰胺腺嘌呤二核苷酸磷酸而发挥其抑菌作用。这些化合物不是电子受体，并且是一些吡啶核苷酸连接的脱氢酶的已知抑制剂。
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