Oyamada H, Tabei T, Yoneyama T, Eguchi K, Orii H, Terui S
Tohoku J Exp Med. 1978 Feb;124(2):145-51. doi: 10.1620/tjem.124.145.
One hundred and six patients having adenocarcinoma of the lung were studied by whole body bone scanning with 99mTc-phosphates in connection with their clinical stages. Abnormal accumulation was found in 64 patients (60%). There were 64 patients who received surgical treatment. Among these 64 patients, 38 underwent bone scanning within 3 months after the establishment of their clinical stages. Twenty-two of them were classified as Stage I clinically. Pathological stage classification after the surgery revealed these 22 to be classified into 3 groups; 6 for Pathological Stage I, 4 for Pathological Stage II and 12 for Pathological Stage III. None of these 6 in Stage I showed abnormal accumulations. However, 1 of 4 in Stage II and 6 of 12 in Stage III were found to have abnormal accumulations. Therefore, if bone scintigrams had been taken into consideration for clinical stage classification, 7 patients would have never been placed into Clinical Stage I and could be expected more precise treatment. The authors recommend application of the results of whole body bone scanning to stage classification of adenocarcinoma of the lung. Needle biopsy is also recommended to confirm the metastasis at the site of radioisotope accumulation in the rib.
对106例肺癌腺癌患者进行了研究，采用99mTc-磷酸盐全身骨扫描，并结合其临床分期。64例患者（60%）发现有异常聚集。有64例患者接受了手术治疗。在这64例患者中，38例在临床分期确定后3个月内进行了骨扫描。其中22例临床分类为I期。手术后的病理分期显示，这22例分为3组：病理I期6例，病理II期4例，病理III期12例。I期的这6例均未显示异常聚集。然而，II期的4例中有1例，III期的12例中有6例被发现有异常聚集。因此，如果在临床分期分类中考虑骨闪烁显像，7例患者就不会被归入临床I期，有望得到更精确的治疗。作者建议将全身骨扫描结果应用于肺癌腺癌的分期分类。还建议进行针吸活检，以确认肋骨放射性同位素聚集部位的转移情况。
