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1
Parental factors associated with rigidity in Huntington's disease.与亨廷顿舞蹈症僵化相关的父母因素。
J Med Genet. 1980 Apr;17(2):112-4. doi: 10.1136/jmg.17.2.112.
2
Relation of parental age to rigidity in Huntington's disease.父母年龄与亨廷顿舞蹈病僵硬症状的关系。
J Med Genet. 1974 Jun;11(2):136-40. doi: 10.1136/jmg.11.2.136.
3
The relation of the sex of choreic and rigid subjects to the age at onset of Huntington's disease.舞蹈症和强直型亨廷顿病患者的性别与发病年龄的关系。
Clin Genet. 1974;5(3):248-53. doi: 10.1111/j.1399-0004.1974.tb01690.x.
4
Factors influencing dementia and epilepsy in Huntington's disease of early onset.
Acta Neurol Scand. 1980 Nov;62(5):305-11. doi: 10.1111/j.1600-0404.1980.tb03041.x.
5
Physostigmine in rigid Huntington's disease.毒扁豆碱治疗僵直型亨廷顿舞蹈病
Confin Neurol. 1973;35(5):312-5. doi: 10.1159/000102851.
6
Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting.亨廷顿舞蹈症发病年龄与父亲年龄之间的负相关关系提示基因印记的参与。
Am J Hum Genet. 1992 Mar;50(3):528-35.
7
Validation and aplication of an interval factor in estimating age at onset of Huntington's disease.一种间隔因素在估计亨廷顿舞蹈病发病年龄中的验证与应用
J Med Genet. 1978 Feb;15(1):23-6. doi: 10.1136/jmg.15.1.23.
8
Abnormal MRI signal in the rigid form of Huntington's disease.亨廷顿舞蹈病刚性形式中的异常磁共振成像信号。
J Neurol Neurosurg Psychiatry. 1991 Oct;54(10):888-91. doi: 10.1136/jnnp.54.10.888.
9
Age at onset in Huntington's disease: effect of line of inheritance and patient's sex.亨廷顿舞蹈症的发病年龄：遗传系谱及患者性别的影响
J Med Genet. 1991 Aug;28(8):515-9. doi: 10.1136/jmg.28.8.515.
10
Patterns of inheritance of the symptoms of Huntington's disease suggestive of an effect of genomic imprinting.亨廷顿舞蹈症症状的遗传模式提示了基因组印记效应。
J Med Genet. 1991 Apr;28(4):224-31. doi: 10.1136/jmg.28.4.224.

引用本文的文献

1
Patterns of inheritance of the symptoms of Huntington's disease suggestive of an effect of genomic imprinting.亨廷顿舞蹈症症状的遗传模式提示了基因组印记效应。
J Med Genet. 1991 Apr;28(4):224-31. doi: 10.1136/jmg.28.4.224.

本文引用的文献

1
Statistical aspects of the analysis of data from retrospective studies of disease.疾病回顾性研究数据的统计分析方面
J Natl Cancer Inst. 1959 Apr;22(4):719-48.
2
Relation of parental age to rigidity in Huntington's disease.父母年龄与亨廷顿舞蹈病僵硬症状的关系。
J Med Genet. 1974 Jun;11(2):136-40. doi: 10.1136/jmg.11.2.136.
3
The relation of the sex of choreic and rigid subjects to the age at onset of Huntington's disease.舞蹈症和强直型亨廷顿病患者的性别与发病年龄的关系。
Clin Genet. 1974;5(3):248-53. doi: 10.1111/j.1399-0004.1974.tb01690.x.
4
A sex related factor in the inheritance of Huntington's chorea.
Ann Hum Genet. 1974 Jan;37(3):255-60. doi: 10.1111/j.1469-1809.1974.tb01833.x.
5
The relation of sex of affected parent to the age at onset of Huntington's disease.患病亲本的性别与亨廷顿舞蹈症发病年龄的关系。
J Med Genet. 1973 Dec;10(4):333-6.
6
The relation of some features of Huntington's disease to the age at onset of symptoms in parents.亨廷顿舞蹈症的某些特征与父母症状出现年龄的关系。
Clin Genet. 1972;3(6):477-82. doi: 10.1111/j.1399-0004.1972.tb01484.x.
7
Familial correlations for age at onset and age at death in Huntington's disease.亨廷顿舞蹈症发病年龄与死亡年龄的家族相关性。
J Med Genet. 1972 Mar;9(1):23-32. doi: 10.1136/jmg.9.1.23.
8
On the estimation of parental age effects on mutation.关于父母年龄对突变影响的估计。
Ann Hum Genet. 1976 May;39(4):427-31. doi: 10.1111/j.1469-1809.1976.tb00147.x.
9
Validation and aplication of an interval factor in estimating age at onset of Huntington's disease.一种间隔因素在估计亨廷顿舞蹈病发病年龄中的验证与应用
J Med Genet. 1978 Feb;15(1):23-6. doi: 10.1136/jmg.15.1.23.
10
Estimation of the age at onset of Huntington's disease from factors associated with the affected parent.根据与患病亲本相关的因素估算亨廷顿舞蹈症的发病年龄。
J Med Genet. 1975 Mar;12(1):64-9. doi: 10.1136/jmg.12.1.64.

与亨廷顿舞蹈症僵化相关的父母因素。

Parental factors associated with rigidity in Huntington's disease.

作者信息

Brackenridge C J

出版信息

J Med Genet. 1980 Apr;17(2):112-4. doi: 10.1136/jmg.17.2.112.

DOI:10.1136/jmg.17.2.112
PMID:6445983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1048513/
Abstract

The discriminatory power of ten factors has been explored in relation to the presence or absence of muscular rigidity in patients with Huntington's disease. The sex and neurological sign of an affected parent were the only two significant determinants of rigidity or choreoathetosis in offspring. It was shown, using the Mantel-Haenszel method of adjusting for confounding variables that the risk of a patient displaying rigidity (and thereby having a graver prognosis) is five times as great for those with rigid parents as it is for those with non-rigid parents. Additionally, the risk of a patient displaying rigidity is more than three times as great for those with affected fathers as it is for those with affected mothers. Some implications of these findings are discussed.

摘要

针对亨廷顿病患者是否存在肌肉强直的情况，对十个因素的鉴别能力进行了研究。受影响父母的性别和神经学体征是后代出现强直或舞蹈徐动症的仅有的两个重要决定因素。使用曼特尔-海恩泽尔法对混杂变量进行校正后发现，父母患有强直的患者出现强直（进而预后更严重）的风险是非强直父母所生患者的五倍。此外，父亲患病的患者出现强直的风险是母亲患病患者的三倍多。文中讨论了这些发现的一些影响。