持续生长的同种异体反应性细胞毒性T淋巴细胞克隆的精细特异性和细胞溶解活性。
Fine specificity and cytolytic activity of continuously growing alloreactive cytotoxic T lymphocyte clones.
作者信息
Schawaller R, Röllinghoff M, Wagner H
出版信息
Scand J Immunol. 1980;11(4):449-53. doi: 10.1111/j.1365-3083.1980.tb00012.x.
Abstract
The role of Lyt 1+ T-cell-derived secondard CTL inducing factor allowed the cloning of alloreactive cytotoxic T lymphocytes (CTL) by the limiting dilution approach. Several monoclonal cell lines were established in vitro. The lytic activity of some of the cell lines exceeded that of CTL from bulk cultures; that is, 50% of the target cells were lysed at an effector to target cell ratio of 0.04:1. The fine specificity of individual CTL clones is discussed.
摘要
Lyt 1+ T细胞衍生的二级CTL诱导因子的作用使得通过有限稀释法克隆出同种异体反应性细胞毒性T淋巴细胞（CTL）。在体外建立了多个单克隆细胞系。一些细胞系的裂解活性超过了批量培养的CTL；也就是说，在效应细胞与靶细胞比例为0.04:1时，50%的靶细胞被裂解。文中讨论了单个CTL克隆的精细特异性。
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