Heilmann C, Lindl T, Müller W, Pette D
Basic Res Cardiol. 1980 Jan-Feb;75(1):92-6. doi: 10.1007/BF02001399.
Capacity of Ca2+ sequestration was found to be significantly lowered in microsomal preparations of hearts from spontaneously hypertonic rats. A decrease to 40% of the control level was found for basal and extra ATPase. A similar reduction existed in initial and total Ca2+ uptake. These findings are correlated with a lower concentration of the Ca2+ transport ATPase in SDS gel electrophoresis, a lower density of the 7-9 nm intramembraneous particles and higher half-lives of phosphoprotein. Altered contractility of hypertrophied myocardium may thus be partially explained by the dysfunction of the Ca2+ sequestering system.
自发性高血压大鼠心脏微粒体制剂中Ca2+ 螯合能力显著降低。基础ATP酶和额外ATP酶降低至对照水平的40%。初始Ca2+ 摄取和总Ca2+ 摄取也有类似程度的降低。这些发现与SDS凝胶电泳中Ca2+ 转运ATP酶浓度较低、7-9纳米膜内颗粒密度较低以及磷蛋白半衰期较长相关。因此，肥厚心肌收缩性改变可能部分归因于Ca2+ 螯合系统功能障碍。
