[钙离子在牛磺酸抗惊厥作用演变中的作用]
[Role of calcium ions in the evolution of the anticonvulsant effect of taurine].
作者信息
Gurevich V S, Tkachenko E I, Kulikova O G
出版信息
Biull Eksp Biol Med. 1980 Apr;89(4):418-20.
The decreased microsomal Ca++Mg++ATPase activity and lowered level of Ca++ binding by the brain cortex microsomes in seizure prone rats as compared with normal animals have been revealed. Taurine increases these parameters in experiments in vitro. Injection of taurine into the penicillin-provoked epileptogenic focus prevents the seizure reaction in rabbits. This effect is not observed after injection of taurine together with EGTA. The data obtained demonstrate the important role of calcium ions in the anticonvulsant action of taurine.
与正常动物相比，已发现癫痫易感大鼠大脑皮质微粒体中的微粒体Ca++Mg++ATP酶活性降低，且Ca++结合水平降低。在体外实验中，牛磺酸可提高这些参数。向青霉素诱发的癫痫病灶注射牛磺酸可预防家兔的癫痫反应。与EGTA一起注射牛磺酸后未观察到这种效果。所获得的数据表明钙离子在牛磺酸的抗惊厥作用中起重要作用。
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