[Effects of 5 alpha-androstane-3 beta, 17 beta-diol on release of luteinizing hormone (LH) from 36-38 day old male and female rat anterior pituitaries perifused with constant amounts of gonadotrophin releasing hormone (Gn-GH)].

In vitro (perifusion of rat pituitaries) the 5 alpha-androstane-3 beta, 17 beta diol (3 beta diol) exerts inhibitory effects on Gn-RH stimulated LH secretion. The 3 beta diol is more potent at high dose (1 micrograms/ml) than low dose (100 ng/ml) and in the male rat than in the female rat.