A comparison of low dosage trimethoprim/sulfamethoxazole with oxytetracycline in acne vulgaris.

It has been well documented that acne vulgaris usually responds well to long-term systemic tetracycline therapy. However, not all patients respond satisfactorily due to drug intolerance, adverse side effects such as fixed drug eruptions, moniliasis, photosensitivity, and gastric irritation. A double-blind study comparing trimethoprim/sulfamethoxazole with oxytetracycline in the management of acne vulgaris has demonstrated that trimethoprim/sulfamethoxazole is an equally effective and as safe therapeutic agent as oxytetracycline. The results of this study are shown to confirm the works of other authors.