[Metabolism of (1-14C) cholesteryl oleate in the brain of the cat].

Following injection into the cerebral ventricles of conscious cats, cholesteryl oléate (-1-14C) was taken up, hydrolysed and included into a variety of brain lipids. The peak of uptake of cholesteryl oleate (-1-14C) into the brain tissue was obtained 4 h after its administration. The peak of hydrolysis occurred 48 h following intraventricular administration of cholesteryl oleate (-1-14C). Cholesterol esters and free fatty acids decreased, while phospholipids increased within 48 h following injection of labelled cholesteryl oleate. Small percentage of the radioactive material was found in triglycerides, monoglycerides and diglycerides. The radioactive material was found in the brain tissue surrounding the cerebral ventricles and in the cerebral cortex, but in varying amounts: the highest in the thalamus and in the caudate nucleus, while the smallest in the cerebral cortex. The labelled material in these structures increased within first 4 h after its intraventricular injection and thereafter slowly decreased, but by the end of 48 h it was still retained in appreciable amounts.