血液凝固、纤维蛋白溶解和激肽形成的表面激活。
Surface activation of blood coagulation, fibrinolysis and kinin formation.
作者信息
Heimark R L, Kurachi K, Fujikawa K, Davie E W
出版信息
Nature. 1980 Jul 31;286(5772):456-60. doi: 10.1038/286456a0.
DOI:10.1038/286456a0
PMID:6447254
Abstract
The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.
摘要
在高分子量激肽原和高岭土存在的情况下，研究了单链因子XII对血浆前激肽释放酶的激活作用。数据表明，在高岭土存在的情况下，因子XII可以启动血液凝固、纤维蛋白溶解或激肽生成，并且通过将前激肽释放酶转化为激肽释放酶来实现。然后产生一个酶级联反应，在三个密切相关的生理事件中导致纤维蛋白、纤溶酶或缓激肽的形成。
Zotero 插件