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[左旋多巴对心脏手术中儿茶酚胺含量、心肌超微结构及收缩性的影响]

[Effect of L-dopa on the catecholamine content and myocardial ultrastructure and contractility in heart surgery].

作者信息

Zavodskaia I S, Zabrodin O N, Zaskal'ko N I, Kucherenko R P, Nikitina N I

出版信息

Vestn Khir Im I I Grek. 1978 Feb;120(2):13-8.

PMID:644770
Abstract

The fluorometric and histochemical methods of the catecholamines contents determination and electronic microscopy of the ultrastructure were used in the examination of myocardium biopsy preparations. The heart operations were followed with the decrease of catecholamines contents in the myocardium and disorder of the mitochondria ultrastructure. The l-DOPA injection resulted in the increase of the myocardium contractile ability before the operation, but did not prevent from its decrease in the postoperative period. The postoperative l-DOPA administration combined with digitalis, according to the described scheme, contributed to the preservation of the myocardium contractile ability at the optimal level.

摘要

采用荧光法和组织化学法测定儿茶酚胺含量,并运用电子显微镜观察超微结构,对心肌活检标本进行检测。心脏手术后,心肌中儿茶酚胺含量降低,线粒体超微结构紊乱。术前注射左旋多巴可使心肌收缩能力增强,但术后仍未能阻止其下降。按照所述方案,术后给予左旋多巴并联合使用洋地黄,有助于将心肌收缩能力维持在最佳水平。

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