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犬和大鼠离体肺血管中抑制性组胺H2受体的存在。

Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats.

作者信息

Chand N, Altura B M

出版信息

Experientia. 1980 Oct 15;36(10):1186-7. doi: 10.1007/BF01976118.

DOI:10.1007/BF01976118
PMID:6448159
Abstract

Isolated, helically cut strips of pulmonary arteries and veins of dogs, and pulmonary arteries of rats, precontracted with norepinephrine or 5-HT exhibited potent concentration-dependent relaxations to impromidine and dimaprit (histamine H2-agonists). The occurrence of inhibitory histamine H2-receptors in the pulmonary vasculature could play a modulatory role in hypoxic pulmonary vasoconstriction.

摘要

用去甲肾上腺素或5-羟色胺预收缩的犬肺动脉和肺静脉以及大鼠肺动脉的分离螺旋条，对英普咪定和二甲双胍（组胺H2激动剂）表现出强烈的浓度依赖性舒张作用。肺血管中抑制性组胺H2受体的存在可能在低氧性肺血管收缩中起调节作用。

相似文献

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Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats.犬和大鼠离体肺血管中抑制性组胺H2受体的存在。
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本文引用的文献

1
Differential effects of substrate depletion on drug-induced contractions of rabbit aorta.底物耗竭对兔主动脉药物诱导收缩的不同影响。
Am J Physiol. 1970 Dec;219(6):1698-705. doi: 10.1152/ajplegacy.1970.219.6.1698.
2
Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats.低氧大鼠的肺肥大细胞增生和肺组织胺形成能力
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Histamine H1- and H2-receptors in the cat and their roles during alveolar hypoxia.猫体内的组胺H1和H2受体及其在肺泡缺氧过程中的作用。
休克和创伤时网状内皮系统功能与组胺释放：与微循环的关系
Klin Wochenschr. 1982 Sep 1;60(17):882-90. doi: 10.1007/BF01716944.
Respir Physiol. 1977 May;29(3):255-64. doi: 10.1016/0034-5687(77)90002-0.
4
Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology.二甲双胍 -（S-[3-(N,N-二甲基氨基)丙基]异硫脲）- 一种高度特异性的组胺H2受体激动剂。第一部分。药理学。
Agents Actions. 1977 Mar;7(1):31-7. doi: 10.1007/BF01964878.
5
Postnatal changes in response of canine neonatal pulmonary arteries to histamine.犬新生肺动脉对组胺反应的产后变化
Am J Physiol. 1979 Jul;237(1):H76-82. doi: 10.1152/ajpheart.1979.237.1.H76.
6
Histamine H1- and H2-receptors in pulmonary and systemic vasculature of the dog.犬肺血管和体循环血管中的组胺H1和H2受体。
Am J Physiol. 1975 Oct;229(4):1008-13. doi: 10.1152/ajplegacy.1975.229.4.1008.
7
Classification and biological distribution of histamine receptor sub-types.组胺受体亚型的分类及生物学分布
Agents Actions. 1975 Oct;5(4):277-95. doi: 10.1007/BF02205232.