Effects of d-amphetamine and disruption of 5-hydroxytryptaminergic neuronal systems on the synthesis of dopamine in selected regions of the rat brain. - Suppr | 超能文献

Effects of d-amphetamine and disruption of 5-hydroxytryptaminergic neuronal systems on the synthesis of dopamine in selected regions of the rat brain.

作者信息

Lyness W H, Demarest K T, Moore K E

出版信息

Neuropharmacology. 1980 Sep;19(9):883-9. doi: 10.1016/0028-3908(80)90088-x.

DOI:10.1016/0028-3908(80)90088-x

Abstract

摘要

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Effects of d-amphetamine and disruption of 5-hydroxytryptaminergic neuronal systems on the synthesis of dopamine in selected regions of the rat brain.

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Rodent data and general hypothesis: antipsychotic action exerted through 5-Ht2A receptor antagonism is dependent on increased serotonergic tone.啮齿动物数据及一般假说：通过5-羟色胺2A受体拮抗作用发挥的抗精神病作用依赖于血清素能张力的增加。

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An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.脑内含5-羟色胺系统在右旋苯丙胺运动效应中的抑制作用。

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Increased tilt-cage activity after serotonin depletion by 5,7-dihydroxytryptamine.5,7-二羟基色胺使血清素耗竭后倾斜笼活动增加。

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