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[非必需脑脂肪酸的来源:原位合成与外源性摄入(营养因素的影响)]

[Origin of non-essential cerebral fatty acids: in situ synthesis and exogenous intake (influence of nutritional factors)].

作者信息

Bourre J M

出版信息

C R Seances Soc Biol Fil. 1980;174(4):446-56.

PMID:6449231
Abstract

Fatty acids, saturated and monounsaturated of any chain length are synthesized in the brain through different enzymatic mechanisms, with different pathways located in various subcellular particles in defined cells. However when comparising in vitro results and fatty acids used by brain during its development, it is concluded that this organ only synthesized aprox. 60% of the fatty acids it needs. Thus exogenous origin does occur, from blood or even from diet, as shown by using labeled tracing molecules and analysis of under-nutritioned animals (intra-uterine hypotrophy).

摘要

任何链长的饱和脂肪酸和单不饱和脂肪酸都是通过不同的酶促机制在大脑中合成的,不同的途径位于特定细胞的各种亚细胞颗粒中。然而,当比较体外实验结果和大脑发育过程中所使用的脂肪酸时,可以得出结论,这个器官仅合成其所需脂肪酸的约60%。因此,如使用标记示踪分子和对营养不足动物(宫内发育迟缓)的分析所示,脂肪酸确实有外源性来源,来自血液甚至饮食。

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