Wheeler G P, Alexander J A, Adamson D J
Cancer Res. 1980 Oct;40(10):3723-7.
The effects of N,N'-bis(2-chloroethyl)-N-nitrosourea and chlorozotocin upon the proliferation, DNA synthesis, and viability of cultured cells of a sensitive line of L1210 leukemia, a line partially resistant to N,N'-bis(2-chloroethyl)-N-nitrosourea, and a line resistant to cyclophosphamide were determined. The results indicate that neither the effect upon proliferation nor the effect upon DNA synthesis is a good predictor of the extent of cell kill. The similarity of the effects of N,N'-bis(2-chloroethyl)-N-nitrosourea upon these two parameters for the three cell lines indicates that the sensitive and resistant cells are affected to approximately the same extent, but more of the resistant cells survive. Additional studies are required to seek the reasons for this differential survival.
测定了N，N'-双（2-氯乙基）-N-亚硝基脲和氯脲霉素对敏感的L1210白血病细胞系、对N，N'-双（2-氯乙基）-N-亚硝基脲部分耐药的细胞系以及对环磷酰胺耐药的细胞系的增殖、DNA合成及活力的影响。结果表明，无论是对增殖的影响还是对DNA合成的影响，都不是细胞杀伤程度的良好预测指标。N，N'-双（2-氯乙基）-N-亚硝基脲对这三个细胞系的这两个参数的影响相似，表明敏感细胞和耐药细胞受到的影响程度大致相同，但更多的耐药细胞存活下来。需要进一步研究以探寻这种差异存活的原因。
