Gibson S L, Ferguson-Smith M A
Clin Genet. 1980 Aug;18(2):97-102. doi: 10.1111/j.1399-0004.1980.tb01018.x.
One hundred amniotic fluids were tested for the presence of ABH blood group substances. Gestation at amniocentesis ranged from 12 to 28 weeks, with a mean of 16.6 weeks. The secretor status of the fluid was correlated with the secretor status of the baby after birth as determined from a sample of saliva. Fluid and saliva correlated in 98% of cases. It is felt that contamination with blood is likely to be the main source of error in typing amniotic fluids. However, because of the weaker activity of the anti-H serum, the detection of the presence or absence of H-substance can be doubtful if duplicate tests are not carried out. It is recommended that all fluids be checked for contamination with blood and that duplicate assays be done on two successive occasions. If these precautions are taken, the secretor typing of the amniotic fluid accurately reflects the secretor status of the individual foetus. Though probably not of wide application, the test could be of value in prenatal detection of dystrophia myotonica in individual cases.
对100份羊水样本进行了ABH血型物质检测。羊水穿刺时的孕周为12至28周，平均为16.6周。羊水的分泌状态与婴儿出生后的分泌状态相关，后者通过唾液样本确定。在98%的病例中，羊水和唾液的检测结果相符。认为血液污染可能是羊水血型鉴定的主要误差来源。然而，由于抗H血清活性较弱，如果不进行重复检测，H物质存在与否的检测结果可能存疑。建议检查所有羊水样本是否存在血液污染，并连续两次进行重复检测。如果采取这些预防措施，羊水的分泌型分型能够准确反映单个胎儿的分泌状态。尽管该检测可能应用范围不广，但在个别病例的强直性肌营养不良产前检测中可能具有价值。
